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Experimental Study on Effects of "Hua Xian Fang" on Pulmonary Coefficients and Morphological Changes In Rats of Pulmonary Fibrosis
Author(s): 
Pages: 49-51
Year: Issue:  3
Journal: ACTA UNIVERSITATIS TRADITIONIS MEDICALIS SINENSIS PHARMACOLOGIAEQUE SHANGHAI

Keyword:  化纤方肺间质纤维化肺系数形态病理学;
Abstract: 目的观察化纤方对博莱霉素所致肺纤维化大鼠肺组织形态学的影响,探索其阻抑肺纤维化的效应与机制.方法健康SD大鼠,随机分为6组:空白组、模型组、化纤方高剂量组、化纤方中剂量组、化纤方低剂量组、泼尼松组.气管内注入博莱霉素制作大鼠肺纤维化模型,造模后7 d开始治疗,化纤方分别按成人剂量的20倍、10倍、5倍灌胃,连续治疗30 d后处死动物,观察各组治疗后肺组织病理学变化以及比较各组肺系数.结果化纤方各组及泼尼松组肺系数值明显降低(P<0.01),肺组织病理学显示肺泡炎及肺纤维化程度均明显减轻.结论化纤方具有一定的阻抑肺纤维化作用.
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