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Experimental Study on the Effect of "Sticking Powder" on Airway in Asthma Rats
Author(s): 
Pages: 55-57
Year: Issue:  3
Journal: ACTA UNIVERSITATIS TRADITIONIS MEDICALIS SINENSIS PHARMACOLOGIAEQUE SHANGHAI

Keyword:  小儿敷贴粉支气管哮喘炎症外治法动物实验;
Abstract: 目的通过动物实验,观察小儿敷贴粉对哮喘大鼠气道的影响,并探讨其可能的作用机制.方法将SD大鼠随机分为正常对照组、哮喘模型组、中药A组(小儿敷贴粉外敷,日1次)、中药B组(小儿敷贴粉外敷,隔日1次)、西药组(灌胃地塞米松)、中西结合组(小儿敷贴粉、地塞米松),除正常组外,其余各组均采用卵蛋白致成哮喘大鼠模型.经用药物后,观察各组肺组织病理切片情况,各组大鼠气道管壁厚度和面积的变化,以及各组大鼠气道平滑肌厚度和面积的变化.结果肺组织病理观察提示,小儿敷贴粉可以减少支气管黏膜脱落、炎细胞浸润,减轻肺组织小灶性炎症变化;大鼠气道管壁厚度和面积均较模型组明显改善,各药物组大鼠气道平滑肌厚度和面积均较模型组明显改善.结论小儿敷贴粉可明显降低哮喘大鼠肺部炎性细胞的浸润.
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