Author(s): LU Sheng, LI Tao, LI Qixun, LIN Yueqiu, XU Yongqing, LIANG Chongli
Pages: 5706-5707
Year: 2004 Issue:  26
Journal: CHINESE JOURNAL OF CLINICAL REHABILITATION
Keyword:  腱; 人工器官; 生物相容性材料; 移植;
Abstract: BACKGROUND: Human hair keratin artificial tendon (HHKAT) material is a new biological degradable material established in China.OBJECTIVE: To investigate the degradation of HHKAT material in vivo as well as its impact on surrounding tissues.DESIGN: A completely randomized, double-blind controlled trial was conducted.SETTING and PARTICIPANTS: The study was conducted in the Center of Experimental Animals, Kunming General Hospital of Chengdu Military Area Command of Chinese PLA. Twelve male Japanese rabbits(ordinary grade)with a body mass of (2.5 ±0. 5)kg were selected. The animals were fed with standard feed in separate cage.INTERVENTIONS: The rabbits were randomly grouped. HHKAT samples with a disposal time of 30 minutes and 15 minutes were embedded respectively in paraspinal muscle. Normal human hair was used as control group.Materials were accessed respectively at 2, 6, 12 and 24 weeks.MAIN OUTCOME MEASURES: Gross and histological observation of the material was performed in different periods.RESULTS: The degradation speed was different in HHKAT of different disposal time. The 30-minute group had the fastest degradation, which had been absorbed completely in 24 weeks; however, the 15-minute group had only partial degradation in 24 weeks; and control group had no degradation.Histological investigation showed that HHKAT and normal human hair do not evoke obvious inflammatory reactions, and the tissue reaction around gradually decreased with the degradation and absorption of HHKAT.CONCLUSION: HHKAT is a degradable and absorbable material with good biocompatibility, which the degradation speed can be adjusted according to different requirements.