Physicochemical parameters, biocompatibility and mechanical characters of hydroxyapatite coated on titanium alloy implant
Author(s): HU Guangyu, LI Huadong, LI Zhanchun
Pages: 4877-4879
Year: 2004 Issue: 23
Journal: CHINESE JOURNAL OF CLINICAL REHABILITATION
Keyword: 羟基磷灰石类; 涂片层; 植入物; 实验性; 生物相容性材料;
Abstract: BACKGROUND: Hydroxyapatite(HA) coated artificial joint has the property of bone ingrownths fixation presented by intimate ossteointegration with host bedbone, thereby avoiding possible joint subsidence. Commonly used HA coating was deposited mainly by thermal plasma-sprayed process,which inevitably led to change of crystallinity of HA and consequently decreased bioactivity, directly affecting the oseeointegration of artificial joint.OBJECTIVE: To develop a novel porous surfaced titanium alloy coated by HA glass coatings processed with spraying technique. Physiochemical parameters, biocompatibility and mechanical characters were studied to provide experimental basis for future clinical application.DESIGN: A randomized auto-controlled trial.SETTING and SUBJECTS: This study was completed in Shanghai Orthopaedic Research Institute. Forty-eight sets of HA coatings and uncoated titanium alloy substance were prepared by glass-ceramic Industrial Science Iinstitute of Light Industrial Ministry.INTERVENTION: To investigate the optimal sintering temperature, mechanical strength and porous surface microstructure of composite coatings.Totally 48 sets of HA coated and uncoated-Ti-Alloy were implanted at bilateral femoral outer condyle in 24 New Zealand rabbits who were then put to death at 1, 2, 3, 6, 12 weeks postoperatively for taking specimen. The maximum shear strength at bone-HA interface and histological changes were investigated.RESULTS: The optimal sintering temperature was 800 ℃, anti-shearing strength and pressure resistant strength was 18.5 MPa and 170 MPa respectively, aperture rate ranged from10% to 15% with diameter of 30 -70 μm. HA-Ti-Alloy coatings could tightly bond to host bones, which benefit for newly formed bone ingrowing into the crannies and dissolved blocked mesh, meanwhile non-coated substance provided micromelium for connective tissue replacing the died newly formed bone. Shear strength of bone-HA interface was obviously higher than that of non-coating group at any postoperative intervals. (postoperative 3 weeks MD =0. 86, t = 15.61, P ＜ 0.01;postoperative 6 weeks MD = 1.72, t = 18. 19, P ＜ 0. 01; postoperative 12weeks MD=4.42,t=12.84,P ＜0.01).CONCLUSION: This new material could be used in clinical practices as coatings on artificial bone or joint.
Pages: 4877-4879
Year: 2004 Issue: 23
Journal: CHINESE JOURNAL OF CLINICAL REHABILITATION
Keyword: 羟基磷灰石类; 涂片层; 植入物; 实验性; 生物相容性材料;
Abstract: BACKGROUND: Hydroxyapatite(HA) coated artificial joint has the property of bone ingrownths fixation presented by intimate ossteointegration with host bedbone, thereby avoiding possible joint subsidence. Commonly used HA coating was deposited mainly by thermal plasma-sprayed process,which inevitably led to change of crystallinity of HA and consequently decreased bioactivity, directly affecting the oseeointegration of artificial joint.OBJECTIVE: To develop a novel porous surfaced titanium alloy coated by HA glass coatings processed with spraying technique. Physiochemical parameters, biocompatibility and mechanical characters were studied to provide experimental basis for future clinical application.DESIGN: A randomized auto-controlled trial.SETTING and SUBJECTS: This study was completed in Shanghai Orthopaedic Research Institute. Forty-eight sets of HA coatings and uncoated titanium alloy substance were prepared by glass-ceramic Industrial Science Iinstitute of Light Industrial Ministry.INTERVENTION: To investigate the optimal sintering temperature, mechanical strength and porous surface microstructure of composite coatings.Totally 48 sets of HA coated and uncoated-Ti-Alloy were implanted at bilateral femoral outer condyle in 24 New Zealand rabbits who were then put to death at 1, 2, 3, 6, 12 weeks postoperatively for taking specimen. The maximum shear strength at bone-HA interface and histological changes were investigated.RESULTS: The optimal sintering temperature was 800 ℃, anti-shearing strength and pressure resistant strength was 18.5 MPa and 170 MPa respectively, aperture rate ranged from10% to 15% with diameter of 30 -70 μm. HA-Ti-Alloy coatings could tightly bond to host bones, which benefit for newly formed bone ingrowing into the crannies and dissolved blocked mesh, meanwhile non-coated substance provided micromelium for connective tissue replacing the died newly formed bone. Shear strength of bone-HA interface was obviously higher than that of non-coating group at any postoperative intervals. (postoperative 3 weeks MD =0. 86, t = 15.61, P ＜ 0.01;postoperative 6 weeks MD = 1.72, t = 18. 19, P ＜ 0. 01; postoperative 12weeks MD=4.42,t=12.84,P ＜0.01).CONCLUSION: This new material could be used in clinical practices as coatings on artificial bone or joint.
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