Effects of rutaecarpine on ulcerative colitis in mice
Author(s): LIU Baolin, WU Weiwei, JIN Changfeng, WANG Yin
Pages: 1273-1277
Year: 2004 Issue: 11
Journal: CHINESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Keyword: 吴茱萸次碱; 溃疡性结肠炎; 髓过氧化物酶(MPO); PGE2; 肠管收缩;
Abstract: 目的:观察吴茱萸次碱治疗小鼠急性结肠炎的药效及对豚鼠肠道平滑肌运动的影响.方法:2,4-二硝基氯苯(DNCB)/乙醇灌肠制作小鼠急性结肠炎模型,经口给予吴茱萸次碱10、30、100mg·kg-1,观察吴茱萸次碱对小鼠腹泻,组织形态损伤,结肠组织PGE2含量、MPO活力以及对乙酰胆碱、组胺作用下豚鼠离体肠管收缩运动的影响.结果:DNCB诱发结肠炎后,小鼠出现腹泻、充血、溃疡、肠壁增厚等变化.经口给予吴茱萸次碱后,可以显著改善小鼠的腹泻、组织损伤,并且能够降低结肠组织中MPO活性和PGE2的含量,对乙酰胆碱及组胺作用下豚鼠离体肠管收缩亦表现出显著的对抗作用.结论:吴茱萸次碱可以抑制炎性浸润、渗出和组织增生,减轻结肠黏膜的病理损害和抑制肠道平滑肌运动,对实验性动物急性结肠炎有较好的治疗作用.
Pages: 1273-1277
Year: 2004 Issue: 11
Journal: CHINESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Keyword: 吴茱萸次碱; 溃疡性结肠炎; 髓过氧化物酶(MPO); PGE2; 肠管收缩;
Abstract: 目的:观察吴茱萸次碱治疗小鼠急性结肠炎的药效及对豚鼠肠道平滑肌运动的影响.方法:2,4-二硝基氯苯(DNCB)/乙醇灌肠制作小鼠急性结肠炎模型,经口给予吴茱萸次碱10、30、100mg·kg-1,观察吴茱萸次碱对小鼠腹泻,组织形态损伤,结肠组织PGE2含量、MPO活力以及对乙酰胆碱、组胺作用下豚鼠离体肠管收缩运动的影响.结果:DNCB诱发结肠炎后,小鼠出现腹泻、充血、溃疡、肠壁增厚等变化.经口给予吴茱萸次碱后,可以显著改善小鼠的腹泻、组织损伤,并且能够降低结肠组织中MPO活性和PGE2的含量,对乙酰胆碱及组胺作用下豚鼠离体肠管收缩亦表现出显著的对抗作用.结论:吴茱萸次碱可以抑制炎性浸润、渗出和组织增生,减轻结肠黏膜的病理损害和抑制肠道平滑肌运动,对实验性动物急性结肠炎有较好的治疗作用.
Citations
- 炎症性肠病机理研究概况 彭仲生 现代临床医学生物工程学杂志
- Effects of the crude extract of Evodiae Fructus on the intestinal transit in mice Yu LL Planta Medica
- 吴茱萸温中止痛药理研究 张明发 中药材
- Anti-diarrheal effect of water extract of Evodiae Fructus in mice Yu LL Journal of Ethnopharmacology
- Antinociceptive activities of 70% methanal extract of Evodiae Fructus (Fruit of Evoidiae rutaecarp var bodinier and its alkakoidal components Matsuda H Biological and Pharmaceutical Bulletin
- A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa Moon TC Inflammation Research
- Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rats Butzner JD Gut
- 马陆的抗炎药理研究初报 范春雷 中国现代应用药学杂志
- Hapten-induced model of chronic inflammation and ulceration in the rat colon Morris GP Gastroenterology
- 细胞免疫性实验性结肠炎动物模型的建立和髓过氧化物酶及超氧化物歧化酶的检测 朱峰 中国医学科学院学报
- Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid Wallace JL Journal of Pharmacological and Toxicological Methods
- Role of prostaglandins in ulcerative colitis.Enhanced production during active disease and inhibition by sulfasalazine Sharon P Gastroenterology
- Treatment with 16,16'-dimethyl PGE2 before and after induction of colitis with trinitrobenzene sulfonic acid in rats decreases inflammation Allgayer H Gastroenterology
- Rutaecarpine, a quinazolinocarboline alkaloid inhibits prostaglandin production in RAW 264.7 macrophages Woo HG Planta Medica
Related Articles