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Antifungal susceptibility testing of Candida albicans isolated from recurrent vulvovaginal candidiasis
Author(s): 
Pages: 604-606
Year: Issue:  10
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  阴道炎念珠菌性复发性白念珠菌药敏试验抗真菌药唑类;
Abstract: 目的:研究复发性念珠菌性阴道炎(RVVC)最主要的病原菌,即白念珠菌对唑类抗真菌药物的敏感性.方法:对从RVVC患者阴道中分离出的102株白念珠菌,采用美国国家临床实验标准委员会(NCCLS)抗真菌药物敏感试验分会公布的<酵母菌的液基稀释法抗真菌药物敏感试验参考方案>(M-27A方案)进行体外药敏试验.结果:氟康唑(FCZ)对102株白念珠菌的药敏试验示,37株白念珠菌最小抑菌浓度(MIC)≥64.000μg/mL,57株MIC>0.125μg/mL、<64.000μg/ML,8株MIC≤0.125μg/mL.伊曲康唑(ICZ)对37株耐FCZ的白念珠菌药敏试验示,35株MIC≥16.000μg/mL,仅2株MIC<16.000μg/mL.结论:①NCCLSM-27A方案操作简便,MIC的一致性及重复性好,可作为体外抗真菌药敏感性试验的一种较好方法.②37株耐FCZ的白念珠菌对ICZ体外药敏试验结果表明,FCZ和ICZ可能具有相似的抗真菌作用机制.
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