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The transplacental antibody transfer after maternal immunization with different Shigella conjugate vaccine
Author(s): 
Pages: 658-661
Year: Issue:  8
Journal: CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY

Keyword:  福氏2a痢疾结合疫苗宋内痢疾结合疫苗母体免疫;
Abstract: 目的以小鼠为试验动物模型,用不同的痢疾多糖-蛋白结合疫苗免疫母鼠,观察IgG抗体的母婴传递情况.方法用福氏2a痢疾多糖-重组铜绿假单胞菌外毒素A(rEPA)结合疫苗(F2a-O-SP-rEPA)和宋内痢疾多糖-重组铜绿假单胞菌外毒素A结合疫苗(S-O-SP-rEPA)分别皮下免疫母鼠,待其怀孕、分娩,用ELISA分别检测母体、子体小鼠的IgG抗体滴度.结果子体小鼠出生第2周的IgG抗体水平较高,随着小鼠周龄的增加,抗体水平逐渐下降.结论痢疾多糖-蛋白结合疫苗免疫母体后,诱导的特异性抗体可经母体传递给子体,抗体滴度随时间的推移而逐渐降低.
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