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The Influence of Acupuncture on TNF-α and IL-4 in Experimental Allergic Neuritis
Author(s): 
Pages: 43-45
Year: Issue:  7
Journal: SHANGHAI JOURNAL OF ACUPUNCTURE AND MOXIBUSTION

Keyword:  针刺实验性变态反应性神经炎肿瘤坏死因子白细胞介素4;
Abstract: 目的探讨肿瘤坏死因子-α(TNF-α)和白细胞介素-4(IL-4)与实验性变态反应性神经炎(EAN)发病的关系,从细胞因子水平研究针刺疗法对本病的免疫调节作用.方法40只大鼠分为正常对照组、模型组、针刺组、药物组,建立大鼠EAN动物模型,观察大鼠发病率及致病程度,针刺组取腰4夹脊、足三里、悬钟穴,药物组用泼尼松灌胃给药.采用双抗体夹心ELISA法,检测大鼠血清的TNF-α和IL-4的含量变化.结果模型组TNF-α含量较正常组明显升高.针刺组和药物组均能降低TNF-α的含量,使其水平接近正常,尤以药物组抑制作用明显.IL-4的含量各组间均无明显差异.结论提示本病存在Th1/Th2细胞因子间的失衡,其中以Th1型细胞占优势.针刺主要是通过抑制TNF-α等Th1细胞,来重建细胞因子间的平衡.
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