The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Conversion of Taxane Glycosides to 10-Deacetylbaccatin Ⅲ
Author(s): 
Pages: 1088-1092,1097
Year: Issue:  6
Journal: JOURNAL OF FUDAN UNIVERSITY(NATURAL SCIENCE)

Keyword:  10-DAB Ⅲ紫杉烷类化合物木糖基资源利用;
Abstract: 红豆杉是我国珍稀植物,含有多种紫杉烷类化合物.以紫杉醇提取过程中的废料作为原料,首次将含7-木糖基-10-去乙酰基紫杉醇、7-木糖基-10-去乙酰基三尖杉宁碱和7-木糖基-10-去乙酰基紫杉醇C三种化合物的混合物通过氧化、水解反应脱去紫杉烷类化合物C-7位上的木糖基,然后进行肼解反应脱去C-13位上的侧链,最后利用重结晶纯化,得到10-去乙酰基巴卡亭Ⅲ(10-DAB Ⅲ).实验过程中用液质联用(LC/MS/MS)鉴定反应产物,通过核磁共振确认得到10-DAB Ⅲ.结果表明,含10-去乙酰基巴卡亭Ⅲ母环结构的紫杉烷类化合物--尤其是含木糖基的紫杉烷类化合物是能够转化为10-DAB Ⅲ的.由于10-DAB Ⅲ是半合成紫杉醇的原料,这对于提高紫杉醇的产量,缓解紫杉醇资源短缺的现状有着积极的作用.
Related Articles
loading...