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Detection of the interleukin levels in serum and sputum in old patients with chronic bronchitis and its significance
Author(s): 
Pages: 610-612
Year: Issue:  6
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  支气管炎慢性白细胞介素类;
Abstract: 目的:探讨老年慢性支气管炎患者血清及痰液白细胞介素水平变化及其意义.方法:以放射免疫法测定42例老年慢性支气管炎急性发作患者,37例老年慢性支气管炎缓解期患者以及31例健康对照者血清及痰液中IL-2、IL-4、IL-6、IL-8水平,并对以上三组上述细胞因子水平进行统计学分析.结果:急性组与缓解组血清与痰液中IL-4、IL-6、IL-8水平均高于正常对照组(P<0.05),其中,急性组血清与痰液中上述细胞因子水平较对照组更高(P<0.05).但是,急性组与缓解组IL-2水平低于正常对照组(P<0.05),其中,急性组较缓解组更低(P<0.05).同时,直接相关分析表明,急性组血清IL-6与IL-8、IL-6与IL-4呈正相关关系(P<0.05);痰液中IL-4、IL-6、IL-8相互间呈正相关关系(P<0.05).结论:IL-2、IL-4、IL-6、IL-8均参与老年慢性支气管炎的发病机制,在慢性气道炎症病理过程及急性发作中起着重要作用.这些指标的测定对于老年慢性支气管炎的诊断及炎症反应评估有一定的临床价值.
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