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Effect of traditional Chinese medicine absorption serum on expression of protooncogene c-fos in cultured cardiac myocyte induced by angiotensin Ⅱ
Author(s): 
Pages: 355-357
Year: Issue:  6
Journal: CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE IN INTENSIVE AND CRITICAL CARE

Keyword:  开心胶囊心肌肥大原癌基因;
Abstract: 目的:探讨中药开心胶囊抗心肌肥大的作用机制.方法:通过分离、培养乳鼠心肌细胞,给予不同剂量开心胶囊和开搏通干预,采用血管紧张素Ⅱ(AngⅡ)诱导心肌细胞原癌基因c-fos表达,用逆转录-聚合酶链反应(RT-PCR)法检测心肌细胞c-fos表达.结果:不同剂量开心胶囊含药血清与开搏通一样均具有抑制心肌细胞c-fos表达的作用(P均<0.05).结论:开心胶囊有抑制心肌肥大的作用.
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