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The effect of amifostine on the cytotoxicity from cisplatine and cyclophosphamide
Author(s): 
Pages: 314-316
Year: Issue:  5
Journal: JOURNAL OF SOUTHEAST UNIVERSITY(MEDICAL SCIENCE EDITION)

Keyword:  氨磷汀顺铂环磷酰胺化学治疗细胞毒性骨髓有核细胞微核率小鼠;
Abstract: 目的:评价氨磷汀对顺铂和环磷酰胺诱导正常细胞毒性的保护作用及对化疗药物抗肿瘤作用的影响.方法:用MTT法测定顺铂对体外培养的Hela、Ho-8910肿瘤细胞的抑制作用,实验组加顺铂前30 min经氨磷汀处理,对照组则不需处理,比较两组细胞增殖的抑瘤率.同时观察注射顺铂、环磷酰胺前30 min注射氨磷汀与不注射组小鼠骨髓有核细胞的微核率.结果:用600 mg·L-1氨磷汀在体外加顺铂前30 min加入Hela、Ho-8910肿瘤细胞,和对照组比较两组的肿瘤细胞增殖没有差异(P>0.05);而体内实验得到,顺铂、环磷酰胺腹腔注射正常小鼠前30 min注射氨磷汀与不注射氨磷汀比较,单独用顺铂、环磷酰胺的小鼠骨髓有核红细胞微核率高于氨磷汀保护组(P<0.05).结论:氨磷汀腹腔注射正常小鼠可明显降低顺铂、环磷酰胺引起正常小鼠的细胞毒性,同时氨磷汀不影响顺铂对Hela、Ho-8910肿瘤细胞的化疗疗效.
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