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The effects of mifepristone on the fetal liver,kindey,and brain through the analysis of the expression of Pur - α
Author(s): 
Pages: 8-9,23
Year: Issue:  5
Journal: CHINESE JOURNAL OF BIRTH HEALTH AND HEREDITY

Keyword:  米非司酮损伤Pur-α免疫组化;
Abstract: 目的探讨米非司酮对中孕胎儿肝、肾、脑组织损伤的可能性.方法采用免疫组化方法,检测17例米非司酮中期引产胎儿肝、肾、脑组织DNA损伤基因Pur-α的表达.实验组按孕龄分为:Ⅰ组6例孕12~15w;Ⅱ组8例孕16~23w;Ⅲ组3例孕24-28w.水囊引产胎儿5例,设为对照组;结果实验组pur-α呈强阳性表达(P<0.01).对照组pur-α均呈阴性表达.结论中期妊娠使用米非司酮可造成胎儿肝、肾、脑组织的损伤.pur-α是检测基因损伤最敏感的指标之一.
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