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The Study on HLA-Cw Polymorphism from Xi'an Han Population by PCR-sequence Specific Oligonucleotide Probe
Author(s): 
Pages: 197-199
Year: Issue:  4
Journal: JOURNAL OF FORENSIC MEDICINE

Keyword:  HLA-CwPCR-SSOP多态性西安汉族;
Abstract: 目的研究西安汉族HLA-Cw基因座遗传多态性,建立西安汉族HLA-Cw基因座基因频率数据库.方法采用序列特异性寡核苷酸探针杂交技术(PCR-SSOP)对130位西安汉族无关个体HLA-Cw基因座进行基因分型.结果共检出16种等位基因,基因频率分布在0.0077~0.158 8,其中HLA-Cw*01、03、07基因频率较高,PCR-SSOP分型技术使西安汉族HLA-Cw空白频率降至0.018 2.结论西安汉族HLA-Cw基因座基因型分布符合Handy-Weinberg平衡定律,所得到的基因频率数据可为临床器官移植配型、人类学、法医学提供重要的群体遗传学资料.
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