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p57kip2 and tumor
Author(s): 
Pages: 100-102
Year: Issue:  2
Journal: FOREIGN MEDICAL SCIENCES (ONCOLOGY SECTION)

Keyword:  细胞周期蛋白类细胞周期蛋白质依赖激酶类肿瘤;
Abstract: p57kip2基因的编码产物是一种广泛的细胞周期蛋白依赖性激酶(CDK)的抑制蛋白.它通过调控细胞周期进程,参与肿瘤细胞的增殖、分化与凋亡.在多种肿瘤中均发现p57kip2基因表达异常,且在某些肿瘤中是一种独立的预后因素,与肿瘤的发生、发展及预后有着密切关系.
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