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Vascular endothelial growth factor C promotes lymphangiogenesis in tumour metastasis
Author(s): 
Pages: 113-115
Year: Issue:  2
Journal: FOREIGN MEDICAL SCIENCES (ONCOLOGY SECTION)

Keyword:  内皮生长因子受体细胞表面淋巴管肿瘤转移;
Abstract: VEGFR-3主要在成熟组织的淋巴管内皮细胞上表达,肿瘤分泌的VEGF-C、VEGF-D与之结合后可诱导淋巴管内皮细胞增殖和迁移,刺激淋巴管的新生,介导肿瘤淋巴道的转移.通过竞争性抑制VEGFR-3的信号转导可有效阻止肿瘤淋巴管的转移,最终达到提高治疗肿瘤的作用.
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