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Observation of the Efficacy of Terbinafine on Itraconazole-Resistant,Recurrent and Reinfected Onychomycosis
Author(s): 
Pages: 214-217
Year: Issue:  4
Journal: JOURNAL OF NAVAL GENERAL HOSPITAL

Keyword:  特比萘芬伊曲康唑甲真菌病疗效观察;
Abstract: 目的观察特比萘芬对伊曲康唑治疗甲真菌病抵抗及复发或再感染者的疗效,为难治性、复发性甲真菌病治疗提供临床经验.方法我们选取伊曲康唑治疗甲真菌病抵抗4例及复发或者再感染13例,共17例门诊患者,特比萘芬口服,250 mg,1 /d,连续12周,观察治疗结束时和随访24周的疗效和不良反应.结果治疗结束时真菌学疗效可达88.2%,其中指甲为100%,趾甲为85.7%,随访24周真菌学治愈率为100%.治疗结束时临床疗效有效率达84.2%,其中指甲为66.7%,趾甲为85.7%;随访至24周时有效率为94.1%,指甲100%,趾甲92.9%.仅2例出现了轻度的胃部不适、皮肤瘙痒及头痛.结论特比萘芬对伊曲康唑治疗抵抗及复发或再感染的甲真菌病者疗效好,且耐受性好,不良反应少,安全性高.
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