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huan yuan xing gu zuo gan zuo yu que xue zai guan zhu sun shang bao hu
Author(s): 
Pages: 231-234
Year: Issue:  4
Journal: JOURNAL OF NAVAL GENERAL HOSPITAL

Keyword:  还原性谷胱甘肽再灌注;
Abstract: 缺血再灌注损伤常见于体外循环、失血性休克、脏器移植等,其发生发展的主要机理有自由基损伤、离子分布异常、炎症递质与细胞因子释放以及凋亡等.还原性谷胱甘肽是人体固有的抗氧化物质之一,广泛存在于肝、心、肾、肺、红细胞等多种器官组织中,可通过直接清除自由基、减少自由基生成;调节离子分布;抑制细胞因子合成、减少效应细胞活化、减轻靶细胞损伤;调节凋亡相关基因的平衡等机理,协助机体对抗缺血再灌注损伤.
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