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Combination chemotherapy of weekly paclitaxel and carboplatin in the treatment of advanced non-small cell lung cancer
Author(s): LI Man, FENG Zhongzuo, WANG Xinghai, SUN Zuohua, ZHANG Zhuo, ZHANG Yang
Pages: 317-
319
Year: 2004
Issue:
4
Journal: CHINESE JOURNAL OF CLINICAL ONCOLOGY AND REHABILITATION
Keyword: 肺肿瘤/化学疗法; 紫杉醇; 卡铂;
Abstract: 目的评价紫杉醇每周用药联合卡铂治疗晚期非小细胞肺癌的疗效和毒副反应.方法采用紫杉醇75 mg/m2静脉滴注,第1,8,15天给药,卡铂第2天静滴,28 d重复.结果全部病例均可评价疗效,无完全缓解病例,部分缓解率为40.0%(10/25).初治、复治者有效率分别为42.8%(3/7)和38.8%(7/18,P>0.05).中位生存期13.5个月.0.5,1,2年生存率分别为72.0%、52.0%和36.0%.全组毒性反应主要为骨髓抑制、胃肠道反应和脱发.结论紫杉醇每周用药联合卡铂对晚期非小细胞肺癌疗效较好,毒性可耐受.
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