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A Clinic - Pathological Aanalysis of 46 Cases with Gastrointestinal Stromal Tumors
Author(s): LI Jingguo, XU Dai, WANG Cong
Pages: 176-
178
Year: 2004
Issue:
3
Journal: HENAN JOURNAL OF ONCOLOGY
Keyword: 胃肠道间质瘤; 临床病理; 免疫组化;
Abstract: 目的探讨胃肠道间质瘤(GIST)的组织起源、临床病理和免疫组化特点.方法对46例GIST标本进行临床病理观察及免疫组织化学检查.结果 46例GIST中良性8例,交界性14例,恶性24例;瘤细胞为梭形或上皮样,或两者混合存在;免疫组化表型为CD117和CD34,阳性率分别为95.6%及67.4%,Desmin及S-100少数病例灶性阳性.结论 GIST可能起源于多潜能的、卡哈尔间质细胞样的前体细胞,是胃肠道最常见的间叶性肿瘤,有较为独特的组织学形态,免疫组织化学CD117敏感性强、特异性高,是胃肠道间质瘤可靠的标记物;CD34表达率较高,可作为诊断的参考指标.
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