Author(s): ZHENG Ying, ZHU Jiabi, WANG Yueling, SUN Zuozuo
Pages: 1-4
Year: 2004 Issue:  3
Journal: JIANGSU PHARMACEUTICAL AND CLINICAL RESEARCH
Keyword:  尼莫地平; 纳米脂质体; 包封率; 反透析法;
Abstract: 目的建立尼莫地平纳米脂质体的包封率测定方法.方法以高效液相色谱法为分析手段,采用反透析法测定尼莫地平纳米脂质体的包封率.结果反透析法透析平衡时间为6 h,游离药物回收率符合要求;此法测得自制尼莫地平纳米脂质体的平均包封率为85.69%±3.13%,10 h内无渗漏,方法重现性好.结论反透析法便捷、准确,适用于脂溶性药物尼莫地平纳米脂质体的包封率测定.