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The effect of Zhenguanling on Rheumatoid Arthritis
Author(s): 
Pages: 8-11
Year: Issue:  3
Journal: JIANGSU PHARMACEUTICAL AND CLINICAL RESEARCH

Keyword:  抗炎镇痛佐剂性关节炎类风湿;
Abstract: 目的探索镇关灵治疗类风湿性关节炎(rheumatoid arthritis,RA)的作用.方法以佐剂性关节炎(AA)、蛋清性关节炎、角叉菜胶性关节炎为实验病理目标,建立二硝基氟苯所致小鼠迟发型超敏反应(DTH)、棉球肉芽肿及醋酸所致小鼠腹腔毛细血管通透性增高和扭体反应等病理模型.结果镇关灵能显著抑制大鼠佐剂性关节炎、蛋清性关节炎、角叉菜胶所致炎症的足跖肿胀度和棉球肉芽肿,抑制由醋酸引起的小鼠扭体反应和腹腔毛细血管通透性增高,并可抑制DTH.结论镇关灵具有良好的抗炎镇痛免疫抑制作用,对类风湿性关节炎具有明显的预防和治疗作用.
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