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Study on the Factors of Effecting the Suanzaoren Tang Action
Author(s): 
Pages: 34-36
Year: Issue:  3
Journal: JIANGSU PHARMACEUTICAL AND CLINICAL RESEARCH

Keyword:  酸枣仁汤均匀设计;
Abstract: 目的对影响酸枣仁汤药效的因素进行研究.方法采用均匀设计的方法,以旷野法的自发活动次数为指标,对影响酸枣仁汤药效的三个因素:药物剂量、起效时间及给药天数进行研究.结果三个因素中对自发活动次数影响大小依次为:给药天数>起效时间.在选定的剂量范围内,自发活动次数与剂量之间无线性关系;与给药天数、给药后起效时间有依赖关系,且给药天数、给药后起效时间与自发活动次数呈正相关.结论自发活动次数最少的因素组合为:给药1天,给药后30 min后进行实验,药物剂量为12 g/kg.为本方的药理研究和临床应用提供依据.
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