The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
GABA mediaties the inhibitory effect of lateral amygdaloid nucleus stimulation on the acoustic response of neurons in A Ⅰ cortex:An in vivo microiontophoretic study
Author(s): 
Pages: 374-378
Year: Issue:  3
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  lateral amygdaloid nucleusA Ⅰ cortexacoustic responseinhibitionGABA;
Abstract: Experiments were performed on Sprague Dawley rats with multibarrel microelectrode technique. The effects of acoustic response of A Ⅰ cortex neurons produced by electrical stimulation of lateral amygdaloid nucleus (LA) and the influence of GABA were observed. Experimental results showed that iontophoretic administration of GABA caused a pronounced inhibition of the electrical activity of A- Ⅰ neurons. Blockade of GABAA with bicuculline (BIC) facilitated the acoustic response. The acoustic response of A- Ⅰ neurons was inhibited when the LA was stimulated. Iontophoretic application of GABA resulted in a similar inhibitory effect as that of LA stimulation. Blockade of GABAA with bicuculline reversed the inhibitory effect of LA stimulation on the acoustic response of A- Ⅰ neurons. In contrast, application of strychnine, a glycine receptor antagonist, could not reverse the inhibitory effect of LA. Baclofen, a GABAB agonist, did not affect the acoustic response of the auditory neurons. These results indicate that GABA is the ultimate transmitter which mediates the LA stimulation-induced inhibition of the acoustic response of A- Ⅰ neurons in rats, possibly via the GABAAreceptor.
Related Articles
No related articles found