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Effect of acetazolamide on the latency of hyperbaric oxygen-induced convulsion
Author(s): 
Pages: 158-162
Year: Issue:  2
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  高压氧惊厥乙酰唑胺脑血流;
Abstract: 为探讨脑血流调节与氧惊厥的关系,在复制大鼠氧惊厥模型的基础上,采用行为学方法测定氧惊厥潜伏期,并测定不同部位脑组织氧化与抗氧化指标,采用腹腔注射不同剂量脑血管扩张药物乙酰唑胺,观察脑血管扩张对氧化状态以及氧惊厥潜伏期的影响.观察结果为:(1)与生理盐水组相比,乙酰唑胺200、20 mg/kg体重组腹腔给药后氧惊厥潜伏期(纯氧6 ATA暴露)明显缩短(P<0.01),乙酰唑胺2 mg/kg体重组无明显改变(P>0.05);(2)腹腔给乙酰唑胺(20 mg/kg体重)或生理盐水后,各组各部位脑组织GSH-PX无显著差异(P>0.05),但随暴露时间的延长,其活力呈现先升高后降低的趋势;与对照组相比,乙酰唑胺6min组和生理盐水16 min组皮层丙二醛(maleic dialdehyde,MDA)含量均明显增多(P<0.01),乙酰唑胺16 min组海马MDA含量明显增多(P<0.01).结果表明,乙酰唑胺可缩短氧惊厥潜伏期,加重脑组织氧化损伤.
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