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Study on the Synthesis of 2-(4-halobenzoyl)aniline
Author(s): 
Pages: 94-98
Year: Issue:  1
Journal: JOURNAL OF CHEMICAL ENGINEERING OF CHINESE UNIVERSITIES

Keyword:  2-(4-卤代苯甲酰基)苯胺2-(4-氟苯甲酰基)苯胺2-(4-氯苯甲酰基)苯胺2-(4-溴苯甲酰基)苯胺中间体合成;
Abstract: 研究了重要的有机中间体2-(4-卤代苯甲酰基)苯胺的通用合成路线,是以邻苯二甲酸酐为原料,与卤代苯(分别为氟苯、氯苯和溴苯)进行付-克反应得到羧酸;羧酸经酰氯化、酰胺化,制得邻苯甲酰基苯甲酰胺衍生物,然后再经过霍夫曼降解合成了标题化合物.对主要步骤反应条件进行了优化,得出比较合理的条件为:付-克反应,催化剂:AlCl3,配料比:1:2.2:6.4(苯酐:AlCl3:卤代苯);同时使用卤代苯既作反应试剂,又作溶剂,未反应的卤代苯回收套用,使收率基本定量;酰胺化反应氨气流量:10mL·min-1,使反应得以室温进行,无需制冷;四步反应总收率可达70%.
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