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Determination of Metronidazole in Human Plasma by HPLC and its Pharmacokinetics
Author(s): 
Pages: 4-5
Year: Issue:  1
Journal: JIANGSU PHARMACEUTICAL AND CLINICAL RESEARCH

Keyword:  甲硝唑高效液相色谱血药浓度药代动力学;
Abstract: 目的采用高效液相色谱法测定人血浆中甲硝唑浓度.方法以替硝唑为内标,HPLC法测定.结果甲硝唑的线性范围为0.5~20.0 μg·ml-1,回归方程为Y=0.173X-0.0119,r=0.9971,最低检测浓度为0.5 μg·ml-1,日内RSD为1.48%~5.67%,日间RSD为2.36%~7.06%.结论主要药代动力学参数与文献报道相似.
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