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Determination of Glimepiride and Its Stability Study by HPLC
Author(s): 
Pages: 25-27
Year: Issue:  1
Journal: JIANGSU PHARMACEUTICAL AND CLINICAL RESEARCH

Keyword:  高效液相色谱法降血糖药格列美脲;
Abstract: 目的采用高效液相色谱法测定降血糖新药格列美脲及其片剂含量.方法 Lichrospher ODS C18柱为色谱柱,乙腈-0.1%乙酸(50∶50)为流动相,流量1.00 ml/min,检测波长228 nm.结果试验日内差RSD为0.57%,n=15,日间差RSD为1.63%,n=15.线性范围12.5~400 μg/ml,标准曲线:Y=71.583X+0.703,r=0.9997,检测限:0.1 μg/ml.平均回收率为101.2%,RSD为1.89%,n=17.结论本法准确、方便、可靠.测定结果满意,可作为格列美脲及其片剂含量测定方法.
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