Methylenetetrahydrofolate reductase gene polymorphism and susceptibility to peripheral arterial occlusive disease in hypertensive patients
Author(s): LIU Jianwei, YE Ling, LIU Jing, LI Xiaoying
Pages: 4-6
Year: 2004 Issue: 1
Journal: CHINESE JOURNAL OF GERIATRIC HEART BRAIN AND VESSEL DLSEASES
Keyword: 胺氧化还原酶类; 多态性; 限制性片段长度; 动脉闭塞性疾病; 高血压;
Abstract: 目的探讨北京万寿路社区老年人群亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因多态性与原发性高血压(essential hypertension,EH)及EH伴周围动脉闭塞性疾病(peripheral arterial occlusive disease,PAOD)的易感性.方法用聚合酶链反应-限制性片段长度多态性技术,检测了100例健康老年人(NC组)、100例老年EH(EH组)及59例老年EH伴PAOD患者(EH-PAOD组)的MTHFR基因多态性.结果MTHFR等位基因呈多态性.NC组3种基因型频率为:CC,31.0%;CT,50.0%;TT,19.0%.EH组分别为:CC,29.0%;CT,45.0%;TT,26.0%.EH-PAOD组分别为:CC,15.9%;CT,35.5%;TT,48.6%.3组MTHFR基因的C677T单核苷酸突变中T突变位点的频率分别为44.0%、48.5%、64.4%.EH-PAOD组与NC组、EH-PAOD组与EH组比较TT基因型频率和T等位基因频率均呈显著性差异.结论MTHFR基因C677T单核苷酸突变是老年EH伴PAOD的危险因素之一,但可能与老年EH无关.
Pages: 4-6
Year: 2004 Issue: 1
Journal: CHINESE JOURNAL OF GERIATRIC HEART BRAIN AND VESSEL DLSEASES
Keyword: 胺氧化还原酶类; 多态性; 限制性片段长度; 动脉闭塞性疾病; 高血压;
Abstract: 目的探讨北京万寿路社区老年人群亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因多态性与原发性高血压(essential hypertension,EH)及EH伴周围动脉闭塞性疾病(peripheral arterial occlusive disease,PAOD)的易感性.方法用聚合酶链反应-限制性片段长度多态性技术,检测了100例健康老年人(NC组)、100例老年EH(EH组)及59例老年EH伴PAOD患者(EH-PAOD组)的MTHFR基因多态性.结果MTHFR等位基因呈多态性.NC组3种基因型频率为:CC,31.0%;CT,50.0%;TT,19.0%.EH组分别为:CC,29.0%;CT,45.0%;TT,26.0%.EH-PAOD组分别为:CC,15.9%;CT,35.5%;TT,48.6%.3组MTHFR基因的C677T单核苷酸突变中T突变位点的频率分别为44.0%、48.5%、64.4%.EH-PAOD组与NC组、EH-PAOD组与EH组比较TT基因型频率和T等位基因频率均呈显著性差异.结论MTHFR基因C677T单核苷酸突变是老年EH伴PAOD的危险因素之一,但可能与老年EH无关.
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