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Inhibitive effect of interferon-α on hepatic metastasis in human colon cancer orthotopic xenotransplanted in nude mice
Author(s): 
Pages: 812-814
Year: Issue:  11
Journal: CHINESE JOURNAL OF GENERAL SURGERY

Keyword:  结肠肿瘤/病理学肝肿瘤/继发性干扰素α/药理学;
Abstract: 目的研究干扰素α对结肠癌生长和转移的抑制作用.方法完整结肠癌组织块裸鼠结肠肠壁原位种植,建立类似于临床的结肠癌转移模型.种植后第7天开始腹腔内注射生理盐水(对照组),5-氟尿嘧啶(5-FU组),干扰素α 2b(IFN α 2b组),5-FU和干扰素α 2b配伍使用(合用组),共用8周.第9周处死裸鼠,测定肿瘤重量、抑瘤率、肿瘤微血管密度和肝转移情况.结果对照组、5-FU组、干扰素α-2b组和合用组的瘤重依次为(1.53±0.78)g,(0.87±0.59)g,(0.81±0.43)g和(0.23±0.09)g,抑瘤率依次为0%,43.1%,47.1%和84.9%.肝脏转移率依次为85.7%,78.6%,21.4%和0%.干扰素α组和合用组的微血管密度明显低于其他各组.结论干扰素α通过抗肿瘤血管生成,能明显抑制结肠癌的生长和肝转移,且和细胞毒性药物合用疗效更明显.
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