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Clinical study of alteration of intestinal barrier function after colorectal operation
Author(s): 
Pages: 858-860
Year: Issue:  11
Journal: CHINESE JOURNAL OF GENERAL SURGERY

Keyword:  结直肠肿瘤/外科学结直肠肿瘤/病理生理学肠屏障功能;
Abstract: 为探讨大肠癌手术后肠屏障功能的变化,观察20例大肠癌患者手术前后粪便肠道菌群的变化,检测血浆D-乳酸水平血中细菌DNA,并作血细菌培养,观察术后感染并发症.结果显示:术后肠道双歧杆菌/大肠杆菌比值较术前倒置更为显著(0.028±0.07/0.75±0.46,P<0.01);术后24,72h血浆D-乳酸水平分别(4.23±0.28mg/L,3.87±0.32mg/L)较术前(3.12±0.17mg/L)明显升高(P<0.01).APACHEⅡ评分>8的大肠癌患者术后24,72h血浆D-乳酸水平较APACHEⅡ评分<8者显著增高(P<0.01);术前血中细菌DNA、血细菌培养均阴性,术后阳性率则分别为43.3%(13/30)和7%(2/30);术后感染并发症发生率为30%(9/30).提示:大肠癌手术可损害肠屏障功能,导致术后肠道细菌易位.
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