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The theraoeutic effects of hvaluronic acid on preventing and treating pleural thickening in patients with tuberculous pleural effusion
Author(s): 
Pages: 480-481
Year: Issue:  8
Journal: NEW CHINESE MEDICINE

Keyword:  透明质酸结核胸膜肥厚纤维蛋白溶酶原激活物抑制物-1药物疗法;
Abstract: 目的:观察胸腔内注射透明质酸防治结核性胸腔积液胸膜肥厚的疗效.方法:初治的有中等量结核性胸腔积液(B超示积液包裹及胸膜肥厚超过0.2 cm)患者57例,随机分为治疗组32例和对照组25例,两组均按同样的抗结核方案治疗,治疗组抽胸腔积液后注入透明质酸2.5mL,对照组抽胸腔积液后注入生理氯化钠2.5 mL,比较两组的疗效.结果:治疗组胸腔穿刺次数较对照组减少(P<0.05)、胸腔积液完全吸收时间较对照组显著变短(P<0.05)、肺功能指标明显优于对照组(P<0.05);治疗组注药后胸膜厚度[(0.57±0.11)cm]较注药前[(0.92±0.15)cm]减轻(P<0.05),与对照组比较其差异也具统计学意义(P<0.05).治疗组注药后胸腔积液中的蛋白含量、白细胞数、纤维蛋白溶酶原激活物抑制物-1含量较注药前明显下降(均为P<0.05).治疗组未见不良反应.结论:胸腔内注射透明质酸有防治结核性胸腔积液胸膜肥厚的作用.
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