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Levels of TNF- α and IL- 8 in patients with acute psoriasis vuigaris
Author(s): 
Pages: 101-102
Year: Issue:  2
Journal: CHINA JOURNAL OF LEPROSY AND SKIN DISEASES

Keyword:  进行期寻常型银屑病肿瘤坏死因子α白介素-8;
Abstract: 目的:研究进行期寻常型银屑病(acute psoriasis vulgaris,APV)患者血清肿瘤坏死因子α(TNF-α)、白介素-8(IL-8)水平,进一步探讨银屑病的免疫学发病机制.方法:采用放射免疫-饱和液相竞争法,检测APV患者血清TNF-α、IL-8水平,并与病情严重程度皮损面积积分(PASI)进行相关性分析.结果:APV患者血清TNF-α、IL-8水平均明显高于正常人水平(P<0.01),且分别与病情严重程度皮损面积积分(PASI)呈正相关,而两者之间无明显相关性.结论:本研究表明TNF-α、IL-8可能在银屑病的发病过程中起重要的作用,TNF-α/IL-8的拮抗剂可能为银屑病的治疗提供新的思路.
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