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Related Study of FHIT Gene with Osteosarcoma
Author(s): 
Pages: 321-324
Year: Issue:  5
Journal: CHINESE JOURNAL OF CLINICAL ONCOLOGY

Keyword:  FHIT基因骨肉瘤杂合性丢失微卫星序列不稳定性;
Abstract: 目的:探讨FHIT(脆性组氨酸三联体,fragile histamine triad)基因在骨肉瘤发生中的作用.方法:选择FHIT基因内三个微卫星多态标记对20例骨肉瘤进行杂合性丢失(L0H)和微卫星不稳定(MSI)分析.结果:在20例骨肉瘤标本中,LOH的总发生率为35.0%,其中在D3S 1300,D3S 4130和D3S 1234的LOH发生率为27 8%、25.0%、20.0%.MSI总发生率为30.0%,三个位点的MSI发生率分别为22.2%、12.5%、13.3%.微卫星多态分析表明FHIT基因在骨肉瘤中既存在杂合性丢失,又存在微卫星不稳定现象,但以前者为主.结论:FHIT基因参与了骨肉瘤的发生,可能是骨肉瘤候选抑癌基因之一.
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