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Plasma Levels of Interleukin-13 in Patients with Chronic Renal Failure and the Effects of Hemodialysis on its Levels
Author(s): LIU Haiyan, CHEN Xiaowen, JIANG Liming, TANG De, LIANG Dong, LIU Huafeng, XU Yongzhi
Pages: 259-
261
Year: 2003
Issue:
5
Journal: CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN NEPHROLOGY
Keyword: 慢性肾衰竭; 白细胞介素13; 血液透析;
Abstract: 目的:探讨慢性肾衰竭(CRF)不同损害期患者血浆白细胞介素13(IL-13)水平和临床意义以及血液透析(HD)对其影响.方法:应用酶联免疫吸附试验(ELISA)检测CRF患者血浆IL-13水平,对比不同肾功能损害期患者血浆IL-13水平,并与肌酐清除率(Ccr)做直线相关分析,观察HD对尿毒症患者血浆IL-13水平的影响.结果:CRF患者血浆IL-13水平较正常对照组增高,且随着肾功能损害程度的加重而增高,至尿毒症期达到最高,与Ccr呈负相关;初次HD使尿毒症患者血浆IL-13水平降低,维持HD 2个月后,血浆IL-13水平降低更为明显.结论:IL-13可能参与CRF患者免疫炎症调节进程,HD可使其水平降低.
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