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Preliminary Studies on the Accessibility of Amino Acid Residue Sites of PrPC to Bind Protein X
Author(s): 
Pages: 28-32
Year: Issue:  4
Journal: AMINO ACIDS AND BIOTIC RESOURCES

Keyword:  朊病毒分子伴侣可及性;
Abstract: 根据PDB提供的PrPC的原子坐标,利用MSMS程序,对PrPC氨基酸残基溶剂可及表面积进行了计算和分析.结果表明:(1) PrPC氨基酸残基可及性具有总体一致性特点;(2) PrPC蛋白质序列中非保守残基与种间屏障有一定关系;(3) 在PrPC向PrP Sc转变过程中,由于蛋白质X的结合,PrPC可能会出现一定的构象变化,这种变化利于PrPC向PrPSc发生转变.
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