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Effects of castration on apoptosis of rat penis
Author(s): 
Pages: 1-3
Year: Issue:  4
Journal: HEILONGJIANG MEDICINE AND PHARMACY

Keyword:  雄激素一氧化氮合酶细胞凋亡阴茎海绵体;
Abstract: 目的:探讨雄激素对阴茎海绵体结构和功能的影响以及细胞凋亡与NOS活性在阴茎勃起中的关系.方法:将30只成年雄性大白鼠随机分为3组,阉割组、替代组及假手术组,阉割组与替代组分别切除双侧睾丸,其中替代组在切除睾丸后给予睾酮替代.于1周后取阴茎海绵体,用紫外分光光度计测定其一氧化氮合酶(NOS)活性,同时用ISEL法检测其细胞凋亡情况.结果:阉割组海绵体NOS活性下降70%,并出现细胞凋亡(P<0.01),睾酮替代组和对照组NOS活性及细胞凋亡差异无显著性(P>0.05).结论:雄激素可通过调节NOS活性及细胞的增殖与凋亡而维持阴茎海绵体的结构与功能.
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