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Studies on in vitro nasal membrane permeation of calcitonin gene related peptide
Author(s): 
Pages: 24-25
Year: Issue:  4
Journal: HEILONGJIANG MEDICINE AND PHARMACY

Keyword:  降钙素基因相关肽125I标记降钙素基因相关肽二甲倍他环糊精鼻腔给药体外透膜;
Abstract: 目的:对降钙素基因相关肽鼻腔给药制剂的吸收促进剂进行初选.方法:用离体羊鼻粘膜,采用体外透膜实验考察不同浓度的二甲倍他环糊精对125I标记的降钙素基因相关肽羊鼻粘膜渗透系数的影响.结果:随着二甲倍他环糊精浓度的增高,125I标记的降钙素基因相关肽的表观渗透系数增大.结论:初步确定降钙素基因相关肽鼻腔给药的吸收促进剂为4%二甲倍他环糊精.
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