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The Effect of Curcumin on Nephrotoxic Serum Nephritis in Rats
Author(s): 
Pages: 305-308
Year: Issue:  4
Journal: ACTA UNIVERSITATIS MEDICINALIS NANJING

Keyword:  姜黄素肾毒血清肾炎大鼠;
Abstract: 目的:探讨姜黄素对大鼠肾毒血清肾炎的防治作用,为将其应用于临床治疗肾小球肾炎提供实验依据.方法:将雄性SD大鼠随机分成3组:①正常对照组:从尾静脉注射0.5 ml/d生理盐水,连用2日;②模型组:从尾静脉注射兔抗鼠肾毒血清0.5 ml/d,连用2日;③姜黄素组:于尾静脉注射兔抗鼠肾毒血清0.5 ml/d,连用2日,同时腹腔注射姜黄素50 mg@kg-1@d-1.3组大鼠分别于第3、7、14、28天处死,测定各批次大鼠24 h尿蛋白,并观察肾脏病理组织学改变.结果:姜黄素组24 h尿蛋白明显低于模型组(P<0.01),半定量分析显示,姜黄素组肾小球细胞数明显低于模型组(P<0.01);间质炎细胞浸润亦少于模型组(P<0.01);14天后肾小管间质损伤指数姜黄素组也明显好于模型组(P<0.01).结论:姜黄素能明显减轻肾毒血清肾炎蛋白尿程度,抑制肾小球内细胞增殖,减轻肾小管间质损伤及炎细胞浸润,具有肾脏保护作用.
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