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Effects of Different Routes of Adiminstration on Acute Hemorrhagic Necrotizing Pancreati- tis of Rats
Author(s): 
Pages: 325-327,392
Year: Issue:  4
Journal: ACTA UNIVERSITATIS MEDICINALIS NANJING

Keyword:  胰腺炎肿瘤坏死因子-α磷脂酶A2大鼠;
Abstract: 目的:探讨经不同途径给药对急性重症胰腺炎(SAP)大鼠不同脏器损伤的治疗效果.方法:SD大鼠46只,随机分为4组:①组1对照组(假手术组)10只;②组2急性出血坏死性胰腺炎(AHNP)经腹腔动脉给药组12只;③组3 AHNP经尾静脉给药组12只;④组4 AHNP组12只;用药组分别在造模后12 h给药,持续8 h,24 h后取材,测血清磷脂酶A2(PLA2)浓度;观察肝、肺组织中肿瘤坏死因子-αmRNA(TNF-α mRNA)的表达变化,取部分肝、肺、胰腺组织作病理学检查.结果:与组4比较,组2门静脉血清PLA2浓度明显降低(P<0.05),肝组织中TNF-α mRNA的表达减少(P<0.05),而肺组织中TNF-αmRNA的表达与组4差异无显著性(P>0.05);组3门静脉血清PLA2浓度下降不明显(P>0.05),肺组织中TNF-α mRNA的表达减少(P<0.05),而肝组织中TNF-αmRNA的表达与组4无差异(P>0.05).结论:药物对胰腺炎的治疗作用与给药途径相关,腹腔动脉灌注可减少SAP大鼠胰腺坏死面积,减低门静脉血PLA2的活性,使肝组织中TNF-α mRNA的表达量明显下降,但对肺组织中TNF-α mRNA的表达影响小.外周静脉给药对肺脏有保护作用.
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