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The Observation of Neurogenesis in the Subventricular Zone in Rats after Transient Fo- cal Cerebral Ischemia
Author(s): 
Pages: 335-337
Year: Issue:  4
Journal: ACTA UNIVERSITATIS MEDICINALIS NANJING

Keyword:  脑缺血神经再生室下带大鼠;
Abstract: 目的:观察大鼠短暂性局灶性脑缺血后侧脑室嘴侧的室下带(SVZ)神经细胞再生的时间规律.方法:行线栓法制作局灶性脑缺血模型,用BrdU标记再生的神经细胞,再用免疫组织化学SP法检测含BrdU的细胞.观察短暂性局灶性脑缺血后1、4、7、10、14天SVZ神经细胞再生的数量.结果:缺血后4天BrdU阳性细胞明显增加,7天时达到峰值,随后开始下降,在14天时明显下降,但仍高于正常组.结论:短暂性局灶性脑缺血可促进室下带的神经细胞再生,提示脑有自我修复的潜在能力.
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