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The Expression of HSP70 in the Global Cerebral Ischemia Reperfusion and It's Relation to the Ischemic Tolerance
Author(s): 
Pages: 338-340
Year: Issue:  4
Journal: ACTA UNIVERSITATIS MEDICINALIS NANJING

Keyword:  全脑缺血脑缺血再灌热休克蛋白70缺血耐受大鼠;
Abstract: 目的:研究不同时间大鼠全脑缺血预处理诱导热休克蛋白70(HSP70)的表达及其与缺血耐受间的关系.方法:用改良的四动脉阻断法制备全脑缺血模型,分别预缺血1、2、5、10 min.2天后用免疫组化SP法检测海马CA1区HSP70的表达,相同的预缺血分组间隔2天再次给予20 min的全脑缺血,5天后观察海马CA1区的病理学改变.结果:预缺血1 min组未见HSP70表达,2 min组少量表达,5 min组大量表达,10 min组表达减少.预缺血1 min组和10 min组再缺血后CA1区锥体细胞大量坏死,2 min组和5 min组坏死细胞较少.结论:HSP70是脑缺血敏感的应激标志,与脑缺血耐受的机制有关,在一定的缺血时间窗内存在量效关系.
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