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Microsatellite Instability in Gastric Cancer
Author(s): 
Pages: 347-349
Year: Issue:  4
Journal: ACTA UNIVERSITATIS MEDICINALIS NANJING

Keyword:  胃肿瘤微卫星不稳定性;
Abstract: 目的:探讨微卫星不稳定性(MSI)在胃癌中的发生规律及其与胃癌临床病理的关系.方法:对30例胃癌及癌旁正常组织石蜡切片提取DNA,应用银染PCR-SSCP技术检测5个MSI.结果:胃癌组织MSI的发生率为23.3%,其中高频MSI(MSI-H)3例,低频MSI(MSI-L)4例.5个位点中以BAT-26的阳性率最高,为13.3%.胃窦癌MSI的发生率显著高于贲门癌(P<0.05),MSI与性别、年龄、细胞分化程度、淋巴结转移、肿瘤TNM分期无关.结论:MSI的发生率与所选位点有关;MSI更多见于胃窦癌,MSI在胃癌的发生发展中可能具有重要作用.
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