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The Dynamic Change of TGF-β1 and Type Ⅰ, Type Ⅲ Collagen after Arterial Intimal Injury
Author(s): 
Pages: 353-355
Year: Issue:  4
Journal: ACTA UNIVERSITATIS MEDICINALIS NANJING

Keyword:  动脉损伤增殖胶原转化生长因子β1;
Abstract: 目的:探讨动脉内膜损伤后转化生长因子β1(TGF-β1)和Ⅰ、Ⅲ型胶原的动态变化及与内膜增殖的关系.方法:在已建立的兔腹主动脉内膜损伤后狭窄模型上,采用免疫组化和原位杂交方法,检测TGF-β1和Ⅰ、Ⅲ型胶原的表达.结果:内膜损伤后2周TGF-β 1和Ⅰ型胶原的表达显著增多,并逐渐增加至术后4个月.正常血管Ⅲ胶原mRNA的表达极低,损伤后1周迅速增加,至4周达到峰值.结论:Ⅰ、Ⅲ型胶原的交替分泌导致内膜损伤后狭窄的形成.TGF-β1对胶原的产生有促进作用.
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