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tu zuo dong mai nei pi sun shang hou zuo sha tan dui zhuan hua sheng chang yin zi 1 he xing jiao yuan biao da de ying xiang
Author(s): 
Pages: 395-397
Year: Issue:  4
Journal: ACTA UNIVERSITATIS MEDICINALIS NANJING

Keyword:  血管紧张素Ⅱ受体拮抗剂动脉损伤再狭窄转化生长因子β1Ⅰ型胶原;
Abstract: 目的:探讨血管紧张素Ⅱ受体拮抗剂缬沙坦对兔髂动脉内皮损伤后转化生长因子β1(TGF-β1)和Ⅰ型胶原表达的影响.方法:将实验动物随机分为普通饲料喂饲组、高脂饮食喂饲+动脉内皮损伤组和高脂饮食喂饲+动脉内皮损伤+缬沙坦治疗组,观察3组兔髂动脉壁的TGF-β1、Ⅰ型胶原表达及内膜增生情况.结果:组2、组3TGF-β1、Ⅰ型胶原蛋白表达均显著高于组1,而组3TGF-β1、Ⅰ型胶原蛋白表达显著低于组2.此外,TGF-β1的表达与Ⅰ型胶原的表达水平两者成正相关,还观察到TGF-β1、Ⅰ型胶原表达水平与内膜/中膜比值成正相关.结论:缬沙坦对内皮损伤后的血管病变有部分保护作用,其机制可能是部分通过下调TGF-β1的表达,减轻血管损伤后Ⅰ型胶原沉积及新生内膜的增生.
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