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Research Progress on Mutual Regulation of Redox Homeostasis and Clock Genes and Its Application Prospect in Space Medicine
Author(s): 
Pages: 80-88
Year: Issue:  1
Journal: Space Medicine & Medical Engineering

Keyword:  redoxcircadian rhythmmicrogravityspace biology;
Abstract: Redox signal is an important regulator of intracellular homeostasis and many biological processes are capable to response to it.Studies have demonstrated that redox oscillates in the body and its period is consistent with that of the clock genes.With the deepening of the researches,large amount of evidence indicates that the transcriptional/translational feedback loops mechanism of circadian rhythm and the non-transcriptional oscillatory mechanism of redox are mutually regulated.The two mechanisms therefore are coupled to produce a timing system with high flexibility.Long-term exposure to microgravity can cause circadian rhythm disorders and oxidative stress damages to the body,increase the health risks of astronauts,and lead to a decline in mission performance and alertness.At present,the effect of microgravity environment on oxidative stress has been studied in depth,but the effect of microgravity on the molecular mechanism of circadian rhythm is rarely studied,and the molecular mechanism of interaction between them has not been fully elucidated.In this paper,the transcriptional oscillation of clock genes and non-transcriptional oscillation of redox were reviewed,the regulation relationship between them and the influence of microgravity on them were summarized.It may serve as a good reference for further deepening the research of space biology and formulating the comprehensive countermeasures of space medicine.
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