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Sequencing and analysis of genomic structure of two distinct TT virus variants related to a novel genetic group
Author(s): 
Pages: 307-310
Year: Issue:  4
Journal: CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY

Keyword:  TT病毒基因型分子流行病学;
Abstract: 目的测定2株TTV高度变异株全基因序列,对其基因结构、基因分型及分子流行病学分析. 方法从2名感染TTV高度变异株的婴儿血清中抽提其DNA,用long inverted PCR扩增出全基因组并测定其序列,同时对测序结果进行分析.根据测定的序列设计引物,对人群中此类变异株的感染情况进行研究. 结果首次报道了TTV一个新基因群--第5基因群;测定了该基因群中2株变异株的全基因序列.该基因群在小于30日龄、1~6月龄、7~12月龄的婴儿中检出率分别为0、27.3%、39.5%,献血员中检出率为45.8%. 结论虽然第5基因群基因组核酸序列呈高度异质性,但其基本结构及功能与已报道的TTV各基因群十分相似;婴儿中该基因群的感染主要与环境因素有关.
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