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Analysis of association between TNF β*2 allele and lupus nephritis
Author(s): 
Pages: 65-66
Year: Issue:  2
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  肿瘤坏死因子β等位基因红斑狼疮系统性;
Abstract: 目的:进一步探讨肿瘤坏死因子β(TNF β)基因在系统性红斑狼疮(SLE)发病中的作用.方法:采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP)基因分型方法,检测98例SLE患者TNF β等位基因,分析了TNF β等位基因与SLE患者某些临床指标的相关性.结果:携带TNF β*2等位基因的SLE患者的肾炎发生率显著高于未携带TNF β*2等位基因的SLE患者(P<0.05).结论:TNF β*2等位基因可能与狼疮性肾炎的发病相关.
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