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Analysis of association between TNF β*2 allele and lupus nephritis
Author(s):
ZHANG Jianglin
,
LIU Zhiran
,
XIE Hongfu
,
SHI Wei
,
LI Ning
Pages:
65
-
66
Year:
2003
Issue:
2
Journal:
JOURNAL OF CLINICAL DERMATOLOGY
Keyword:
肿瘤坏死因子β
;
等位基因
;
红斑狼疮
;
系统性
;
Abstract:
目的:进一步探讨肿瘤坏死因子β(TNF β)基因在系统性红斑狼疮(SLE)发病中的作用.方法:采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP)基因分型方法,检测98例SLE患者TNF β等位基因,分析了TNF β等位基因与SLE患者某些临床指标的相关性.结果:携带TNF β*2等位基因的SLE患者的肾炎发生率显著高于未携带TNF β*2等位基因的SLE患者(P<0.05).结论:TNF β*2等位基因可能与狼疮性肾炎的发病相关.
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