The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
Study of Simulated Weightlessness by Tail Suspension on Changes of Ocular Hemodynamics and Axis in Rats
Author(s): 
Pages: 401-405
Year: Issue:  5
Journal: Space Medicine & Medical Engineering

Keyword:  simulated weightlessnesscentral retinal arteryhemodynamicsocular axis;
Abstract: Objective To investigate the effects of simulated weightlessness on the ocular hemodynamics of central retinal artery and ocular axis in rats.Methods A total of 25 healthy rats were randomly divided into 5 groups:the control group,the tail suspension group for 1 day,the tail suspension group for 4 days,the tail suspension group for 7 days and the tail suspension group for 14 days.The ocular hemodynamics of central retinal artery(CRA)and the ocular axis in rats were detected and analyzed by color Doppler ultrasonography.The hemodynamic parameters included the peak maximum systolic velocity(PSV),the end diastolic velocity(EDV),the pulsatility index(PI)and the resistance index(RI).Changes of optic disc and retina in rats were observed by color fundus photography.Results Compared with the control group,the PSV and EDV were increased in the tail suspension group for 1 day(P<0.05).The PSV and EDV were decreased significantly in the tail suspension group for 14 days compared with the tail suspension group for 1 day(P<0.05).There was no significant difference in PI and RI in the control and suspended groups.Compared with the tail suspension group for 4 days,the axial length of the eye was shorter(P<0.05)in the tail suspension group for 7 days.Compared with the tail suspension group for 7 days,the axial length of the eye was shorter(P<0.05)in the tail suspension group for 14 days.During the observation period,there was no obvious papilloedema,retinal hemorrhage,exudation and other pathological changes in color fundus photography in each group.Conclusion Simulated weightlessness by tail suspension for 14 dhas a certain effect on the fundus blood flow in rats.With the extension of the tail suspension time,the axis of the eye becomes shorter.No obvious damage to the optic disc and retina is observed in the observation period.
Related Articles
No related articles found