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Interleukin-6 measurement in serum and urine in patients with lupus nephritis and its clinical significance
Author(s): 
Pages: 93-95
Year: Issue:  2
Journal: JOURNAL OF NANJING MILITARY MEDICAL COLLEGE

Keyword:  白细胞介素6狼疮性肾炎血清尿;
Abstract: 目的: 探讨细胞因子在狼疮性肾炎发病机制中的作用.方法:应用白细胞介素6(IL-6)依赖细胞株KD83,检测狼疮性肾炎(LN)患者活动期组、稳定期组和正常对照组血清和尿中IL-6的活性.结果:活动期组LN患者血清和尿中IL-6活性均明显高于稳定期组和正常对照组(P<0.01 ),而稳定期组LN患者和正常对照组之间无显著差异(P>0.05);活动期组LN患者血清和尿中IL-6活性均与血沉(ESR)呈正相关(r=0.683 0和r=0.576 7,P<0.05),而与血清补体C3、抗核抗体(ANA)、抗ds-DNA抗体均无相关关系;活动期组LN患者血清IL-6活性与血清IgG呈正相关(r=0.835 0,P<0.01),与补体C4呈负相关(r=-0.598 0,P<0.05).结论:活动期LN患者血和尿的IL-6活性均增高,提示IL-6在LN的发病机制中起着一定的作用,血和尿的IL-6活性可作为观察LN患者病情的活动性指标.
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